| Summary: | Background: World population is rapidly aging, and the elderly are most at risk of cognitive
impairment. Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEAS) have an essential
effect on neuroprotection and might effectively improve cognition and memory.
Objectives: This study aimed to investigate the relationship between the level of DHEA and
memory function in the elderly.
Materials & Methods: The present study was a cross-sectional analytical study, and the study
population included the elderly (age 60 years and older) living in Rasht City, the north of Iran,
in 2020. The participants completed a demographic questionnaire and Wechsler Memory Scale
(WMS), and their serum DHEA levels were measured by the hormonal automation method. The
data were analyzed by SPSS v. 23, using t-test, the one-way Analysis of Variance (ANOVA),
Pearson and Spearman correlation coefficient.
Results: The participants included 100 older people (57 females and 43 males) with a Mean±SD
age of 67.38±5.39 years. There was no correlation between serum DHEA concentrations with a
total score of the WMS (r=0.117, P=0.247). However, the correlation between the DHEA level and
the scores of personal and current information and visual reproduction subscales were statistically
significant (r=0.219, P=0.029; r=0.206, P=0.04).
Conclusion: The study indicates that the total memory score was not associated with the level of
serum DHEA.
|
|---|
