Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP,...

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Main Authors: Yun Qian, Qixin Han, Wei Chen, Jialin Song, Xiaotian Zhao, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Chemistry
Subjects:
platelet-rich plasma
growth factors
stem cells
cell differentiation
musculoskeletal regeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2017.00089/full
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spelling doaj-60ed539de62246f9805dd2e1335cc6432020-11-24T22:41:44ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462017-10-01510.3389/fchem.2017.00089292052Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal RegenerationYun Qian0Yun Qian1Qixin Han2Wei Chen3Wei Chen4Jialin Song5Jialin Song6Xiaotian Zhao7Yuanming Ouyang8Yuanming Ouyang9Weien Yuan10Cunyi Fan11Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, ChinaRenji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, ChinaDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaStem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.http://journal.frontiersin.org/article/10.3389/fchem.2017.00089/fullplatelet-rich plasmagrowth factorsstem cellscell differentiationmusculoskeletal regeneration
collection DOAJ
language English
format Article
sources DOAJ
author Yun Qian
Yun Qian
Qixin Han
Wei Chen
Wei Chen
Jialin Song
Jialin Song
Xiaotian Zhao
Yuanming Ouyang
Yuanming Ouyang
Weien Yuan
Cunyi Fan
spellingShingle Yun Qian
Yun Qian
Qixin Han
Wei Chen
Wei Chen
Jialin Song
Jialin Song
Xiaotian Zhao
Yuanming Ouyang
Yuanming Ouyang
Weien Yuan
Cunyi Fan
Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
Frontiers in Chemistry
platelet-rich plasma
growth factors
stem cells
cell differentiation
musculoskeletal regeneration
author_facet Yun Qian
Yun Qian
Qixin Han
Wei Chen
Wei Chen
Jialin Song
Jialin Song
Xiaotian Zhao
Yuanming Ouyang
Yuanming Ouyang
Weien Yuan
Cunyi Fan
author_sort Yun Qian
title Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
title_short Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
title_full Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
title_fullStr Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
title_full_unstemmed Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
title_sort platelet-rich plasma derived growth factors contribute to stem cell differentiation in musculoskeletal regeneration
publisher Frontiers Media S.A.
series Frontiers in Chemistry
issn 2296-2646
publishDate 2017-10-01
description Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.
topic platelet-rich plasma
growth factors
stem cells
cell differentiation
musculoskeletal regeneration
url http://journal.frontiersin.org/article/10.3389/fchem.2017.00089/full
work_keys_str_mv AT yunqian plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
AT yunqian plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
AT qixinhan plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
AT weichen plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
AT weichen plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
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AT xiaotianzhao plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
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AT cunyifan plateletrichplasmaderivedgrowthfactorscontributetostemcelldifferentiationinmusculoskeletalregeneration
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