Computational prediction of potential siRNA and human miRNA sequences to silence orf1ab associated genes for future therapeutics against SARS-CoV-2

Computational prediction of potential siRNA and human miRNA sequences to silence orf1ab associated genes for future therapeutics against SARS-CoV-2

The coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by an RNA virus termed as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 possesses an almost 30kbp long genome. The genome contains open-reading frame 1ab (ORF1ab) gene, the largest one of SARS-CoV-2, enc...

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Bibliographic Details
Main Authors: Mahedi Hasan, Arafat Islam Ashik, Md Belal Chowdhury, Atiya Tahira Tasnim, Zakia Sultana Nishat, Tanvir Hossain, Shamim Ahmed
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Informatics in Medicine Unlocked
Subjects:
RNAi Therapeutics
Gene silencing
miRNA
siRNA
COVID-19
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914821000599

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