Putative biomarkers for predicting tumor sample purity based on gene expression data

Putative biomarkers for predicting tumor sample purity based on gene expression data

Abstract Background Tumor purity is the percent of cancer cells present in a sample of tumor tissue. The non-cancerous cells (immune cells, fibroblasts, etc.) have an important role in tumor biology. The ability to determine tumor purity is important to understand the roles of cancerous and non-canc...

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Bibliographic Details
Main Authors: Yuanyuan Li, David M. Umbach, Adrienna Bingham, Qi-Jing Li, Yuan Zhuang, Leping Li
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Genomics
Subjects:
Tumor purity
RNA-seq
Gene expression
XGBoost
Gradient boosted trees
And machine learning
Online Access:https://doi.org/10.1186/s12864-019-6412-8

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