Synthesis and Antimicrobial Activity of Some Novel 5-Alkyl-6-Substituted Uracils and Related Derivatives

Synthesis and Antimicrobial Activity of Some Novel 5-Alkyl-6-Substituted Uracils and Related Derivatives

6-Chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloro-pyrimidines 4a-c, which were selectively hydrolyzed...

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Bibliographic Details
Main Authors:	Nasser R. El-Brollosy, Ali A. El-Emam, Omar A. Al-Deeb, Abdulghafoor A. Al-Turkistani
Format:	Article
Language:	English
Published:	MDPI AG 2011-06-01
Series:	Molecules
Subjects:	synthesis 5-alkyluracils 8-alkyltetrazolo[1,5-f]pyrimidine-5,7(3H,6H)-dione antimicrobial activity
Online Access:	http://www.mdpi.com/1420-3049/16/6/4764/

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