Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines

Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines

Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC...

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Bibliographic Details
Main Authors: Yerly Vargas Casanova, Jorge Antonio Rodríguez Guerra, Yadi Adriana Umaña Pérez, Aura Lucía Leal Castro, Giovanni Almanzar Reina, Javier Eduardo García Castañeda, Zuly Jenny Rivera Monroy
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
lactoferricin B
E. coli
breast cancer
cytotoxic effect
antibacterial activity
synthetic peptides
Online Access:https://www.mdpi.com/1420-3049/22/10/1641

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