Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice

Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice

Abstract Background Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macrophages into an anti-inflammatory phenotype thus alleviating insulin resist...

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Bibliographic Details
Main Authors: Jieqing Gao, Yu Cheng, Haojie Hao, Yaqi Yin, Jing Xue, Qi Zhang, Lin Li, Jiejie Liu, Zongyan Xie, Songyan Yu, Bing Li, Weidong Han, Yiming Mu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Insulin resistance
Decitabine
Macrophage polarization
Diabetes
Online Access:http://link.springer.com/article/10.1186/s13287-019-1338-2

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