Clinical therapeutic effect of two therapies on circumscribed choroidal hemangioma

• Main Authors: Le-Le Huang, Lei Chen, Yue-Dong Hu, Rui Hua, Li-Min Liu
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-03-01
• Series: Guoji Yanke Zazhi
• Subjects: circumscribed choroidal hemangioma; photodynamic therapy; transpupillary thermotherapy; Verteporfin
• Online Access: http://www.ies.net.cn/cn_publish/2014/3/201403033.pdf

AIM:To observe the clinical therapeutic effect of photodynamic therapy(PDT)and transpupillary thermotherapy(TTT)on circumscribed choroid hemangioma(CCH).<p>METHODS: Totally 24 cases(24 eyes)of CCH were selected in this study. Twelve of them had undergone TTT, and the other 12 were treated by PDT. The changes of tumors were examined by best corrected visual acuity, results of fundus photography, and direct ophthalmoscopy; the changes of tumors' sizes and heights were examined by B-ultrasound examination and coloured doppler imaging; the presence of serous subretinal fluid were examined by optical coherence tomography(OCT); the leakage of tumors and complications were analyzed by fluorescence fundus angiography(FFA)and indocyanine green angiography(ICGA).<p>RESULTS: In all cases, the tumors shrinked back, the blood flows tuned negative, the fluorescence leakages lessened and the serous retinal detachments resolved completely according to OCT, FFA, ICGA and coloured doppler imaging. In the 12 patients treated by TTT, visual acuity improved in 33.3%, unchanged in 33.3%, and droped in 33.3% too; the results of fundus examinations showed obvious pigmentation and atrophy tumor with organized scar. In the 12 patients treated by PDT, visual acuity improved in 66.7%, unchanged in 33.3%, and none droped; the results of fundus examinations showed slight pigment derangement, atrophy tumor tuned white, and normal blood vessel undamaged.<p>CONCLUSION: Both TTT and PDT can make the tumor atrophy and the exudation absorbed. Unlike TTT, PDT damages little normal tissue, and has higher security.