Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain...

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Main Authors: Nicholas A. Courtney, Huan Bao, Joseph S. Briguglio, Edwin R. Chapman
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12015-w
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spelling doaj-60a9c376ca40470abac94a203d8f4cc12021-05-11T12:40:34ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12015-wSynaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexinNicholas A. Courtney0Huan Bao1Joseph S. Briguglio2Edwin R. Chapman3Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-MadisonDepartment of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-MadisonDepartment of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-MadisonDepartment of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-MadisonThe molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain of syt1, and not complexin, is solely responsible for the reduction of the spontaneous release at the presynapsehttps://doi.org/10.1038/s41467-019-12015-w
collection DOAJ
language English
format Article
sources DOAJ
author Nicholas A. Courtney
Huan Bao
Joseph S. Briguglio
Edwin R. Chapman
spellingShingle Nicholas A. Courtney
Huan Bao
Joseph S. Briguglio
Edwin R. Chapman
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
Nature Communications
author_facet Nicholas A. Courtney
Huan Bao
Joseph S. Briguglio
Edwin R. Chapman
author_sort Nicholas A. Courtney
title Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_short Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_full Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_fullStr Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_full_unstemmed Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_sort synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain of syt1, and not complexin, is solely responsible for the reduction of the spontaneous release at the presynapse
url https://doi.org/10.1038/s41467-019-12015-w
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AT josephsbriguglio synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin
AT edwinrchapman synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin
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