The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evi...

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Main Authors: Maryam Assem, Mathilde Lando, Maria Grissi, Saïd Kamel, Ziad A. Massy, Jean-Marc Chillon, Lucie Hénaut
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Toxins
Subjects:
stroke
dementia
cognitive disorders
uremic toxins
Online Access:http://www.mdpi.com/2072-6651/10/7/303
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spelling doaj-60a91830fd644eab9724392b6981af512020-11-25T00:45:27ZengMDPI AGToxins2072-66512018-07-0110730310.3390/toxins10070303toxins10070303The Impact of Uremic Toxins on Cerebrovascular and Cognitive DisordersMaryam Assem0Mathilde Lando1Maria Grissi2Saïd Kamel3Ziad A. Massy4Jean-Marc Chillon5Lucie Hénaut6Nephrology Department, Amiens University Hospital, 80054 Amiens, FranceNephrology Department, Amiens University Hospital, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceDivision of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, 92100 Paris, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceIndividuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evidence from in vitro studies and in vivo animal experiments suggests that accumulation of uremic toxins may contribute to the pathogenesis of stroke and amplify vascular damage, leading to cognitive disorders and dementia. This review summarizes current evidence on the mechanisms by which uremic toxins may favour the occurrence of cerebrovascular diseases and neurological complications in CKD.http://www.mdpi.com/2072-6651/10/7/303strokedementiacognitive disordersuremic toxins
collection DOAJ
language English
format Article
sources DOAJ
author Maryam Assem
Mathilde Lando
Maria Grissi
Saïd Kamel
Ziad A. Massy
Jean-Marc Chillon
Lucie Hénaut
spellingShingle Maryam Assem
Mathilde Lando
Maria Grissi
Saïd Kamel
Ziad A. Massy
Jean-Marc Chillon
Lucie Hénaut
The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
Toxins
stroke
dementia
cognitive disorders
uremic toxins
author_facet Maryam Assem
Mathilde Lando
Maria Grissi
Saïd Kamel
Ziad A. Massy
Jean-Marc Chillon
Lucie Hénaut
author_sort Maryam Assem
title The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
title_short The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
title_full The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
title_fullStr The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
title_full_unstemmed The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
title_sort impact of uremic toxins on cerebrovascular and cognitive disorders
publisher MDPI AG
series Toxins
issn 2072-6651
publishDate 2018-07-01
description Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evidence from in vitro studies and in vivo animal experiments suggests that accumulation of uremic toxins may contribute to the pathogenesis of stroke and amplify vascular damage, leading to cognitive disorders and dementia. This review summarizes current evidence on the mechanisms by which uremic toxins may favour the occurrence of cerebrovascular diseases and neurological complications in CKD.
topic stroke
dementia
cognitive disorders
uremic toxins
url http://www.mdpi.com/2072-6651/10/7/303
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