Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure. Therefore, to explore the novel anticonvulsive mechanisms, the present study determined the effects of voltage-dependent Na<s...

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Bibliographic Details
Main Authors: Kouji Fukuyama, Yuto Ueda, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceuticals
Subjects:
astrocyte
carbamazepine
lacosamide
zonisamide
microdialysis
hemichannel
Online Access:https://www.mdpi.com/1424-8247/13/6/117

Internet

https://www.mdpi.com/1424-8247/13/6/117

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