Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer.

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer.

Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic l...

Full description

Bibliographic Details
Main Authors:	Lisa Salazar, Tamara Kashiwada, Pavel Krejci, April N Meyer, Malcolm Casale, Matthew Hallowell, William R Wilcox, Daniel J Donoghue, Leslie Michels Thompson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466111/pdf/?tool=EBI

Similar Items

The NF-κB Activating Pathways in Multiple Myeloma
by: Payel Roy, et al.
Published: (2018-05-01)

Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB
by: An Thys, et al.
Published: (2021-01-01)

The Regulation of NF-κB Subunits by Phosphorylation
by: Frank Christian, et al.
Published: (2016-03-01)

Redox-Regulated Pathway of Tyrosine Phosphorylation Underlies NF-κB Induction by an Atypical Pathway Independent of the 26S Proteasome
by: Sarah Cullen, et al.
Published: (2015-02-01)

NF-κB activation by <it>Helicobacter pylori </it>requires Akt-mediated phosphorylation of p65
by: Tomita Mariko, et al.
Published: (2009-02-01)

Tyrosine Phosphorylation Regulates the Activity of Phytochrome Photoreceptors
by: Kazumasa Nito, et al.
Published: (2013-06-01)

Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells
by: Kim KyungMann, et al.
Published: (2010-07-01)

Retraction: NF-κB activation by <it>Helicobacter pylori </it>requires Akt-mediated phosphorylation of p65
by: Tomita Mariko, et al.
Published: (2011-06-01)

Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila.
by: Fan Xia, et al.
Published: (2008-05-01)

Drug inhibition profile prediction for NFκB pathway in multiple myeloma.
by: Huiming Peng, et al.
Published: (2011-03-01)

Type 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.
by: Anne Sofie Andreasen, et al.
Published: (2011-01-01)

A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
by: Xuejie Gao, et al.
Published: (2021-05-01)

The regulation of calpain-2 activity bytyrosine phosphorylation and sumoylationThe regulation of calpain-2 activity by tyrosine phosphorylation and sumoylation
by: Wang,Hsueh-Chun, et al.
Published: (2009)

The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling.
by: Kristine A Drafahl, et al.
Published: (2010-12-01)

Developing novel agents targeting the NF-κB pathway for the treatment of multiple myeloma
by: Varley, Melanie
Published: (2017)

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
by: Aishat Motolani, et al.
Published: (2021-12-01)

Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKβ.
by: April N Meyer, et al.
Published: (2013-01-01)

Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFβ1 Transgenic Mice
by: Eleonora Guadagnin, et al.
Published: (2015-01-01)

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
by: Hyung-Joon Kwon, et al.
Published: (2016-05-01)

Minocycline modulates NFκB phosphorylation and enhances antimicrobial activity against Staphylococcus aureus in mesenchymal stromal/stem cells
by: Alberto Daniel Guerra, et al.
Published: (2017-07-01)

p300/CBP tyrosine phosphorylation in response to dna damage activated by c-Abl tyrosine kinase
by: Ripani, Meri <1977>
Published: (2010)

Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2
by: Gema González-Rubio, et al.
Published: (2021-01-01)

Tyrosine phosphorylation and activation of PYK2 in platelets: involvement in PI 3-kinase activation
by: Sayed, Mohamed Rabie
Published: (2009)

Tyrosine phosphorylation and activation of PYK2 in platelets: involvement in PI 3-kinase activation
by: Sayed, Mohamed Rabie
Published: (2009)

Regulation of activation of NF-κB by Calmodulin in T-lymphocytes
by: Oruganti, Sreenivasa Rao
Published: (2011)

Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.
by: Yusuke Okuyama, et al.
Published: (2016-01-01)

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1
by: Muhammad Erfan Uddin, et al.
Published: (2021-03-01)

Comparison of the Potency of Pterostilbene with NF-κB Inhibitors in Platelet Activation: Mutual Activation by Akt-NF-κB Signaling in Human Platelets
by: Chih-Wei Hsia, et al.
Published: (2021-07-01)

USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-κBp65
by: Lili Zhou, et al.
Published: (2018-11-01)

Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1
by: Ingrid Spaan, et al.
Published: (2021-09-01)

Single TNF<it>α </it>trimers mediating NF-<it>κ</it>B activation: stochastic robustness of NF-<it>κ</it>B signaling
by: Paszek Pawel, et al.
Published: (2007-10-01)

Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M, and NF-H : peptide mapping, phosphorylation and alkylation site identification
by: Mixon, April E.
Published: (2012)

Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.
by: Jia Su, et al.
Published: (2013-01-01)

High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma
by: Chenglong Yue, et al.
Published: (2017-09-01)

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src.
by: Jennifer Ly Tsang, et al.
Published: (2016-01-01)

Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity.
by: Zexi Hu, et al.
Published: (2015-01-01)

Regulation of ROCKI by tyrosine phosphorylation
by: Jheng-Guang Jhong, et al.
Published: (2009)

Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells
by: Alessandro Mattè, et al.
Published: (2021-02-01)

Identification of tyrosine-9 of MAVS as critical target for inducible phosphorylation that determines activation.
by: Chaoyang Wen, et al.
Published: (2012-01-01)

Activation of the transcription factor NF-κB by Campylobacter jejuni
by: Alsayeqh, Abdullah Fayez
Published: (2007)