Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway

Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway

Abstract Background Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in the occurrence and development of pancreatic cancer (PC), which continues to be one of the deadliest malignancies with few effective therapies. The study aimed to investigate the...

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Bibliographic Details
Main Authors: Jingyang Zhou, Haihong Wang, Jinhui Che, Lu Xu, Weizhong Yang, Yunjiu Li, Wuyuan Zhou
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cancer Cell International
Subjects:
microRNA-135b
Jade family PHD finger 1
Protein kinase B/mammalian target of rapamycin pathway
Pancreatic cancer
Stemness
Online Access:http://link.springer.com/article/10.1186/s12935-020-01210-1

Internet

http://link.springer.com/article/10.1186/s12935-020-01210-1

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