Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

Abstract Background The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on physiological functions. We have previously investigated the potential pat...

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Bibliographic Details
Main Authors: Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Translational Medicine
Subjects:
Interleukin-18
Interleukin-18 knockout
Brown adipocytes
Brown adipose tissue
Lipid metabolism
Adipogenesis
Online Access:http://link.springer.com/article/10.1186/s12967-018-1684-3

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