Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptide...

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Main Authors:	Philipp M. Cromm, Sebastian Schaubach, Jochen Spiegel, Alois Fürstner, Tom N. Grossmann, Herbert Waldmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11300

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spelling	doaj-6091ec26a2d4425d83166be139ae90e02021-05-11T11:00:51ZengNature Publishing GroupNature Communications2041-17232016-04-01711710.1038/ncomms11300Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptidesPhilipp M. Cromm0Sebastian Schaubach1Jochen Spiegel2Alois Fürstner3Tom N. Grossmann4Herbert Waldmann5Department of Chemical Biology, Max-Planck-Institute of Molecular PhysiologyTechnische Universität Dortmund, Fakultät für Chemie and Chemische BiologieDepartment of Chemical Biology, Max-Planck-Institute of Molecular PhysiologyTechnische Universität Dortmund, Fakultät für Chemie and Chemische BiologieTechnische Universität Dortmund, Fakultät für Chemie and Chemische BiologieDepartment of Chemical Biology, Max-Planck-Institute of Molecular PhysiologyBicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.https://doi.org/10.1038/ncomms11300
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann
spellingShingle	Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides Nature Communications
author_facet	Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann
author_sort	Philipp M. Cromm
title	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_short	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_full	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_fullStr	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_full_unstemmed	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_sort	orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small gtpase-targeting bicyclic peptides
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-04-01
description	Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.
url	https://doi.org/10.1038/ncomms11300
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Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

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