Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation

Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation

Summary: Multiple pathways regulate the repair of double-strand breaks (DSBs) to suppress potentially dangerous ectopic recombination. Both sequence and chromatin context are thought to influence pathway choice between non-homologous end-joining (NHEJ) and homology-driven recombination. To test the...

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Bibliographic Details
Main Authors: Isabella Marcomini, Kenji Shimada, Neda Delgoshaie, Io Yamamoto, Andrew Seeber, Anais Cheblal, Chihiro Horigome, Ulrike Naumann, Susan M. Gasser
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831235X

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