Correlation of serum bFGF and CXCL16 levels with cancer cell growth and invasion in patients with cervical cancer

• Main Authors: Zhi-Hong Liang, Jie-Zhen Chen, Yong-Xue Chen, Xue-Mei Ru, Jia-De Deng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-09-01
• Series: Journal of Hainan Medical University
• Subjects: Cervical cancer; bFGF; CXCL16; Proliferation gene; Invasion gene
• Online Access: http://www.hnykdxxb.com/PDF/201718/31.pdf

Objective: To investigate the correlation of serum bFGF and CXCL16 levels with cancer cell growth and invasion in patients with cervical cancer. Methods: A total of 119 patients who were diagnosed with cervical cancer in Panyu District Shiqiao Hospital and Guangzhou First People's Hospital between October 2013 and October 2016 were collected as observation group, and 100 patients with cervical polyp (benign) who were treated in the hospitals during the same period were selected as control group. bFGF and CXCL16 levels in serum as well as proliferation and invasion gene expression in cervical lesions were detected, and Pearson test was used to further evaluate the correlation of serum bFGF and CXCL16 levels with cancer cell growth and invasion in patients with cervical cancer. Results: Serum bFGF and CXCL16 levels of observation group were higher than those of control group, and LATS1, SFRP2 and TET1 mRNA expression in cervical tissue were significantly lower than those of control group while HERC4, HMGB-1, HIF-1α, YAP1, Twist and RbAp48 mRNA expression were higher than those of control group; serum bFGF and CXCL16 levels in patients with cervical cancer were negatively correlated with LATS1, SFRP2 and TET1 mRNA expression in cervical tissue, and positively correlated with HERC4, HMGB-1, HIF-1α, YAP1, Twist and RbAp48 mRNA expression. Conclusion: Serum bFGF and CXCL16 levels abnormally increase in patients with cervical cancer, and they are directly correlated with the proliferation and invasion activity of cancer cells.