Correlation of serum bFGF and CXCL16 levels with cancer cell growth and invasion in patients with cervical cancer
Objective: To investigate the correlation of serum bFGF and CXCL16 levels with cancer cell growth and invasion in patients with cervical cancer. Methods: A total of 119 patients who were diagnosed with cervical cancer in Panyu District Shiqiao Hospital and Guangzhou First People's Hospital b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2017-09-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201718/31.pdf |
| Summary: | Objective: To investigate the correlation of serum bFGF and CXCL16 levels with cancer cell
growth and invasion in patients with cervical cancer. Methods: A total of 119 patients who
were diagnosed with cervical cancer in Panyu District Shiqiao Hospital and Guangzhou First
People's Hospital between October 2013 and October 2016 were collected as observation
group, and 100 patients with cervical polyp (benign) who were treated in the hospitals during
the same period were selected as control group. bFGF and CXCL16 levels in serum as well as
proliferation and invasion gene expression in cervical lesions were detected, and Pearson test
was used to further evaluate the correlation of serum bFGF and CXCL16 levels with cancer
cell growth and invasion in patients with cervical cancer. Results: Serum bFGF and CXCL16
levels of observation group were higher than those of control group, and LATS1, SFRP2 and
TET1 mRNA expression in cervical tissue were significantly lower than those of control group
while HERC4, HMGB-1, HIF-1α, YAP1, Twist and RbAp48 mRNA expression were higher
than those of control group; serum bFGF and CXCL16 levels in patients with cervical cancer
were negatively correlated with LATS1, SFRP2 and TET1 mRNA expression in cervical tissue,
and positively correlated with HERC4, HMGB-1, HIF-1α, YAP1, Twist and RbAp48 mRNA
expression. Conclusion: Serum bFGF and CXCL16 levels abnormally increase in patients
with cervical cancer, and they are directly correlated with the proliferation and invasion activity
of cancer cells. |
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| ISSN: | 1007-1237 1007-1237 |