LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.
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| Language: | English |
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Nature Publishing Group
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11961 |
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doaj-608124d888234a85a5fb09ba2ac765002021-05-11T10:39:31ZengNature Publishing GroupNature Communications2041-17232016-06-017111410.1038/ncomms11961LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver developmentDa-Hye Lee0Jae Oh Park1Tae-Shin Kim2Sang-Kyum Kim3Tack-hoon Kim4Min-chul Kim5Gun Soo Park6Jeong-Hwan Kim7Shinji Kuninaka8Eric N. Olson9Hideyuki Saya10Seon-Young Kim11Ho Lee12Dae-Sik Lim13National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyDepartment of Pathology, Yonsei University College of MedicineNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyMedical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-guDivision of Gene Regulation, Institute for Advanced Medical Research, Keio University School of MedicineDepartment of Molecular Biology, University of Texas Southwestern Medical Center at DallasDivision of Gene Regulation, Institute for Advanced Medical Research, Keio University School of MedicineMedical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-guNational Cancer Center, Graduate School of Cancer Science and Policy, Research InstituteNational Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and TechnologyThe Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.https://doi.org/10.1038/ncomms11961 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim |
| spellingShingle |
Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development Nature Communications |
| author_facet |
Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim |
| author_sort |
Da-Hye Lee |
| title |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development |
| title_short |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development |
| title_full |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development |
| title_fullStr |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development |
| title_full_unstemmed |
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development |
| title_sort |
lats-yap/taz controls lineage specification by regulating tgfβ signaling and hnf4α expression during liver development |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-06-01 |
| description |
The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation. |
| url |
https://doi.org/10.1038/ncomms11961 |
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