The amyloid precursor protein is a conserved Wnt receptor

The amyloid precursor protein is a conserved Wnt receptor

The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be. We show that APP...

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Bibliographic Details
Main Authors: Tengyuan Liu, Tingting Zhang, Maya Nicolas, Lydie Boussicault, Heather Rice, Alessia Soldano, Annelies Claeys, Iveta Petrova, Lee Fradkin, Bart De Strooper, Marie-Claude Potier, Bassem A Hassan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
brain development
alzheimer's disease
amyloid precursor protein
wnt
Drosophila
mouse
Online Access:https://elifesciences.org/articles/69199

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