Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

Abstract Recent discoveries have provided valuable insight into the genomic landscape of pediatric low-grade gliomas (LGGs) at diagnosis, facilitating molecularly targeted treatment. However, little is known about their temporal and therapy-related genomic heterogeneity. An adequate understanding of...

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Bibliographic Details
Main Authors: Margot A. Lazow, Lindsey Hoffman, Austin Schafer, Diana S. Osorio, Daniel R. Boué, Sarah Rush, Erin Wright, Adam Lane, Mariko D. DeWire-Schottmiller, Teresa Smolarek, Jared Sipple, Heather Taggert, Jaime Reuss, Ralph Salloum, Trent R. Hummel, Peter de Blank, Natasha Pillay-Smiley, Mary E. Sutton, Anthony Asher, Charles B. Stevenson, Rachid Drissi, Jonathan L. Finlay, Maryam Fouladi, Christine Fuller
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Acta Neuropathologica Communications
Subjects:
Pediatric low-grade gliomas
Genomics
Paired
Recurrence
Tumor evolution
BRAF
Online Access:http://link.springer.com/article/10.1186/s40478-020-01054-w

Internet

http://link.springer.com/article/10.1186/s40478-020-01054-w

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