Film-Forming Systems for Dermal Drug Delivery

• Main Authors: Larissa Carine Pünnel, Dominique Jasmin Lunter
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: Pharmaceutics
• Subjects: film-forming system; topical drug delivery; polymeric formulation
• Online Access: https://www.mdpi.com/1999-4923/13/7/932

Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resistance and compared with conventional semi-solid formulations. Penetration and permeation studies of the formulations indicate a potential utility as transdermal therapeutic systems. They can be used as an alternative to patch systems to administer a variety of drugs in a topical way and may provide sustained release characteristics.