Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

Memories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in hum...

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Main Authors:	Ravi K. Das, Grace Gale, Katie Walsh, Vanessa E. Hennessy, Georges Iskandar, Luke A. Mordecai, Brigitta Brandner, Merel Kindt, H. Valerie Curran, Sunjeev K. Kamboj
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13162-w

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spelling	doaj-606a0f7b9edd4aabbf1cf2a46ff7ac242021-05-11T12:03:59ZengNature Publishing GroupNature Communications2041-17232019-11-0110111010.1038/s41467-019-13162-wKetamine can reduce harmful drinking by pharmacologically rewriting drinking memoriesRavi K. Das0Grace Gale1Katie Walsh2Vanessa E. Hennessy3Georges Iskandar4Luke A. Mordecai5Brigitta Brandner6Merel Kindt7H. Valerie Curran8Sunjeev K. Kamboj9Clinical Psychopharmacology Unit, University College LondonClinical Psychopharmacology Unit, University College LondonClinical Psychopharmacology Unit, University College LondonClinical Psychopharmacology Unit, University College LondonUniversity College Hospital and University College Hospital at Westmoreland StreetPain Management Centre, University College HospitalPain Management Centre, University College HospitalExperimental Clinical Psychology, University of AmsterdamClinical Psychopharmacology Unit, University College LondonClinical Psychopharmacology Unit, University College LondonMemories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in humans.https://doi.org/10.1038/s41467-019-13162-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ravi K. Das Grace Gale Katie Walsh Vanessa E. Hennessy Georges Iskandar Luke A. Mordecai Brigitta Brandner Merel Kindt H. Valerie Curran Sunjeev K. Kamboj
spellingShingle	Ravi K. Das Grace Gale Katie Walsh Vanessa E. Hennessy Georges Iskandar Luke A. Mordecai Brigitta Brandner Merel Kindt H. Valerie Curran Sunjeev K. Kamboj Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories Nature Communications
author_facet	Ravi K. Das Grace Gale Katie Walsh Vanessa E. Hennessy Georges Iskandar Luke A. Mordecai Brigitta Brandner Merel Kindt H. Valerie Curran Sunjeev K. Kamboj
author_sort	Ravi K. Das
title	Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
title_short	Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
title_full	Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
title_fullStr	Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
title_full_unstemmed	Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
title_sort	ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-11-01
description	Memories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in humans.
url	https://doi.org/10.1038/s41467-019-13162-w
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Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

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