The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host. Ectopic expression of the interferon-induced 20-kDa exonuclease ISG20 suppressed repli...

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Bibliographic Details
Main Authors: Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Format: Article
Language:English
Published: American Society for Microbiology 2018-09-01
Series:mSphere
Subjects:
alphavirus
host-pathogen interactions
innate immunity
interferon-stimulated gene
virus-host interactions
Online Access:https://doi.org/10.1128/mSphere.00209-18

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