PATHOLOGY OF ENDOMETRIUM AS «THE UTERINE FACTOR» OF INFERTILITY IS THE IMPORTANT MEDICAL AND SOCIAL PROBLEM IN RUSSIA

• Main Authors: Olga Aleksandrovna Vitkina, Evgenija Borisovna Troik, Irina Nikolaevna Kostjuchek
• Format: Article
• Language: English
• Published: Science and Innovation Center Publishing House 2015-01-01
• Series: Sovremennye Issledovaniâ Socialʹnyh Problem
• Subjects: «uterine factor» of infertility; endometrial hyperplasia; chronic endometritis; recep-tors of estrogens and progesterone; marker of cell proliferation (Ki-67); marker of apoptosis (p53)
• Online Access: http://journal-s.org/index.php/sisp/article/view/1988
• ISSN: 2218-7405

<p>Infertility is the important medical and social problem which decreases the birth rates. Complex examination the women with infertility, including histological, and immunohistochemical study of endometrial biopsies revealed  high percentage of endometrial pathology: endometrial hyperplasia, chronic endometritis and their combination, as so called   «the uterine factor» of  infertility.  In chronic endometritis we observed:  the disturbance in expression of the sex steroids receptors , marker of cell proliferation Ki-67 and marker of apoptosis (p53)  in the endometrium.Тhat creates a pathological syndrome, leading to the development and progression of endometrial hyperplasia.</p>