Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and man

Hepatic localization of macrophage phenotypes during fibrogenesis and resolution of fibrosis in mice and man

Macrophages have been found to both promote liver fibrosis and contribute to its resolution by acquiring different phenotypes based on signals from the micro-environment. The best-characterized phenotypes in the macrophage spectrum are labeled M1 (classically activated) and M2 (alternatively activat...

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Bibliographic Details
Main Authors: Leonie eBeljaars, Marlies eSchippers, Catharina eReker-Smit, Fernando eMartinez, Laura eHelming, Klaas ePoelstra, Barbro N Melgert
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Immunology
Subjects:
Fibrosis
Resolution
cirrhosis
il-12
M2
M1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00430/full

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