Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study

Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study

Abstract Background Musculoskeletal conditions are highly prevalent, and knee OA is most common. Current treatment modalities have limitations and either fail to solve the underlying pathophysiology or are highly invasive. To address these limitations, attention has focused on the use of biologics....

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Bibliographic Details
Main Authors: Ashim Gupta, Nicola Maffulli, Hugo C. Rodriguez, R. Justin Mistovich, Kristin Delfino, Craig Cady, Anne-Marie Fauser, Echo D. Cundiff, Marte A. Martinez, Anish G. Potty
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Musculoskeletal injuries
Knee osteoarthritis
Regenerative medicine
Stem cells
Progenitor cells
Growth factors
Online Access:https://doi.org/10.1186/s13018-021-02672-3

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