Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

(2-(2,4-Dichlorophenyl)-3-(1H-indol-1-yl)-1-(1,2,4-1H-triazol-1-yl)propan-2-ol (8 g), a new 1,2,4-triazole-indole hybrid molecule, showed a broad-spectrum activity against Candida, particularly against low fluconazole-susceptible species. Its activity was higher than fluconazole and similar to voric...

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Bibliographic Details
Main Authors: Fabrice Pagniez, Nicolas Lebouvier, Young Min Na, Isabelle Ourliac-Garnier, Carine Picot, Marc Le Borgne, Patrice Le Pape
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
triazole-indole hybrid
candida species
ergosterol production
phospholipase a2-like activity
in vivo evaluation
Online Access:http://dx.doi.org/10.1080/14756366.2019.1705292

Internet

http://dx.doi.org/10.1080/14756366.2019.1705292

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