Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance

Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance

Abstract Background Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs); however, after 10–12 months, secondary mutations arise that confer...

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Bibliographic Details
Main Authors: Yunhua Xu, Feifei Zhang, Xiaoqing Pan, Guan Wang, Lei Zhu, Jie Zhang, Danyi Wen, Shun Lu
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Cancer Communications
Subjects:
Drug resistance
Target treatment
Lung cancer
Pleural effusion
Patient-derived xenografts
Online Access:http://link.springer.com/article/10.1186/s40880-018-0284-1

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http://link.springer.com/article/10.1186/s40880-018-0284-1

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