Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells in Vitro-Correlation With Alterations in the Expression of Proteins Associated With the Insulin System

Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells in Vitro-Correlation With Alterations in the Expression of Proteins Associated With the Insulin System

Rats intracerebroventricularily (icv) treated with streptozotocin (STZ), shown to generate an insulin resistant brain state, were used as an animal model for the sporadic form of Alzheimer’s disease (sAD). Previously, we showed in an in vivo study that 3 months after STZ icv treatment hippocampal ad...

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Bibliographic Details
Main Authors: Ping Sun, Gabriela Ortega, Yan Tan, Qian Hua, Peter F. Riederer, Jürgen Deckert, Angelika G. Schmitt-Böhrer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
streptozotocin
neural stem cells
proliferation
differentiation
insulin-like growth factor 1 receptor
insulin receptor
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00145/full

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