The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.

Recently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied.In this...

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Main Authors: Derek A Wainwright, Sadhak Sengupta, Yu Han, Ilya V Ulasov, Maciej S Lesniak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2963644?pdf=render
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spelling doaj-60591c64096048608fce567c79a35b732020-11-25T02:40:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-10-01510e1539010.1371/journal.pone.0015390The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.Derek A WainwrightSadhak SenguptaYu HanIlya V UlasovMaciej S LesniakRecently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied.In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma.http://europepmc.org/articles/PMC2963644?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Derek A Wainwright
Sadhak Sengupta
Yu Han
Ilya V Ulasov
Maciej S Lesniak
spellingShingle Derek A Wainwright
Sadhak Sengupta
Yu Han
Ilya V Ulasov
Maciej S Lesniak
The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
PLoS ONE
author_facet Derek A Wainwright
Sadhak Sengupta
Yu Han
Ilya V Ulasov
Maciej S Lesniak
author_sort Derek A Wainwright
title The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
title_short The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
title_full The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
title_fullStr The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
title_full_unstemmed The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
title_sort presence of il-17a and t helper 17 cells in experimental mouse brain tumors and human glioma.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2010-10-01
description Recently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied.In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma.
url http://europepmc.org/articles/PMC2963644?pdf=render
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