Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular...

Full description

Bibliographic Details
Main Authors: Frank Weinberg, Nithya Ramnath, Deepak Nagrath
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
ROS
mitochondria
tumorigenesis
tumor microenvironment
stroma
tissue infiltrating lymphocytes
metabolism
Online Access:https://www.mdpi.com/2072-6694/11/8/1191
id doaj-604d430966944051a005d8499ecf4699
record_format Article
spelling doaj-604d430966944051a005d8499ecf46992020-11-24T22:20:48ZengMDPI AGCancers2072-66942019-08-01118119110.3390/cancers11081191cancers11081191Reactive Oxygen Species in the Tumor Microenvironment: An OverviewFrank Weinberg0Nithya Ramnath1Deepak Nagrath2Division of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USADivision of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USAReactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.https://www.mdpi.com/2072-6694/11/8/1191ROSmitochondriatumorigenesistumor microenvironmentstromatissue infiltrating lymphocytesmetabolism
collection DOAJ
language English
format Article
sources DOAJ
author Frank Weinberg
Nithya Ramnath
Deepak Nagrath
spellingShingle Frank Weinberg
Nithya Ramnath
Deepak Nagrath
Reactive Oxygen Species in the Tumor Microenvironment: An Overview
Cancers
ROS
mitochondria
tumorigenesis
tumor microenvironment
stroma
tissue infiltrating lymphocytes
metabolism
author_facet Frank Weinberg
Nithya Ramnath
Deepak Nagrath
author_sort Frank Weinberg
title Reactive Oxygen Species in the Tumor Microenvironment: An Overview
title_short Reactive Oxygen Species in the Tumor Microenvironment: An Overview
title_full Reactive Oxygen Species in the Tumor Microenvironment: An Overview
title_fullStr Reactive Oxygen Species in the Tumor Microenvironment: An Overview
title_full_unstemmed Reactive Oxygen Species in the Tumor Microenvironment: An Overview
title_sort reactive oxygen species in the tumor microenvironment: an overview
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2019-08-01
description Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.
topic ROS
mitochondria
tumorigenesis
tumor microenvironment
stroma
tissue infiltrating lymphocytes
metabolism
url https://www.mdpi.com/2072-6694/11/8/1191
work_keys_str_mv AT frankweinberg reactiveoxygenspeciesinthetumormicroenvironmentanoverview
AT nithyaramnath reactiveoxygenspeciesinthetumormicroenvironmentanoverview
AT deepaknagrath reactiveoxygenspeciesinthetumormicroenvironmentanoverview
_version_ 1725773879160340480

Similar Items