Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular...

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Bibliographic Details
Main Authors: Frank Weinberg, Nithya Ramnath, Deepak Nagrath
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
ROS
mitochondria
tumorigenesis
tumor microenvironment
stroma
tissue infiltrating lymphocytes
metabolism
Online Access:https://www.mdpi.com/2072-6694/11/8/1191
Description
Summary:Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.
ISSN:2072-6694

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