CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.

CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.

Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an evolutionarily conserved calcium-regulated, guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor. While an important intracellular signaling protein for CD117+ mast cells (MCs), its roles in other immune cells is less...

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Bibliographic Details
Main Authors: Saijun Zhou, Kumiko Tanaka, Meredith O'Keeffe, Miao Qi, Fatima El-Assaad, James C Weaver, Gang Chen, Christopher Weatherall, Ying Wang, Bill Giannakopoulos, Liming Chen, DeMint Yu, Matthew J Hamilton, Lislaine A Wensing, Richard L Stevens, Steven A Krilis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4794117?pdf=render

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