Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response

Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response

Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options....

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Main Authors: Kirsten van Gysen, Andrew Kneebone, Thomas Eade, Alexander Guminski, George Hruby
Format: Article
Language:English
Published: Karger Publishers 2018-11-01
Series:Case Reports in Oncology
Subjects:
Immunotherapy
Radiation therapy
Renal cell carcinoma
Targeted therapy
Online Access:https://www.karger.com/Article/FullText/493913
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spelling doaj-604b6d804d854a0fabffcf2dac8b14c62020-11-24T21:40:06ZengKarger PublishersCase Reports in Oncology1662-65752018-11-0111375676210.1159/000493913493913Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment ResponseKirsten van GysenAndrew KneeboneThomas EadeAlexander GuminskiGeorge HrubyClear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options. RCC is considered to be radioresistant, however we report the case of a patient with progression on targeted therapy and immunotherapy who achieved a substantial and sustained local, and possibly abscopal, response to low dose palliative radiation therapy.https://www.karger.com/Article/FullText/493913ImmunotherapyRadiation therapyRenal cell carcinomaTargeted therapy
collection DOAJ
language English
format Article
sources DOAJ
author Kirsten van Gysen
Andrew Kneebone
Thomas Eade
Alexander Guminski
George Hruby
spellingShingle Kirsten van Gysen
Andrew Kneebone
Thomas Eade
Alexander Guminski
George Hruby
Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
Case Reports in Oncology
Immunotherapy
Radiation therapy
Renal cell carcinoma
Targeted therapy
author_facet Kirsten van Gysen
Andrew Kneebone
Thomas Eade
Alexander Guminski
George Hruby
author_sort Kirsten van Gysen
title Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_short Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_full Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_fullStr Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_full_unstemmed Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_sort advanced renal cell cancer and low-dose palliative radiation treatment: a case of a substantial and sustained treatment response
publisher Karger Publishers
series Case Reports in Oncology
issn 1662-6575
publishDate 2018-11-01
description Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options. RCC is considered to be radioresistant, however we report the case of a patient with progression on targeted therapy and immunotherapy who achieved a substantial and sustained local, and possibly abscopal, response to low dose palliative radiation therapy.
topic Immunotherapy
Radiation therapy
Renal cell carcinoma
Targeted therapy
url https://www.karger.com/Article/FullText/493913
work_keys_str_mv AT kirstenvangysen advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT andrewkneebone advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT thomaseade advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT alexanderguminski advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT georgehruby advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
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