A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

Abstract Background The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by which TIME affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC). Methods A total of 2195 eligib...

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Bibliographic Details
Main Authors: Zaoqu Liu, Yuyuan Zhang, Chengcheng Shi, Xueliang Zhou, Kaihao Xu, Dechao Jiao, Zhenqiang Sun, Xinwei Han
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
Immunotherapy
Tumor immunological microenvironment
Immune escape
Molecular subtype
Online Access:https://doi.org/10.1186/s12967-020-02697-y

Internet

https://doi.org/10.1186/s12967-020-02697-y

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