Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss

Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss

Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness. Here we suggest that the mechanism of conscious access is related to a general dynamic...

Full description

Bibliographic Details
Main Authors: Camilo Miguel Signorelli, Lynn Uhrig, Morten Kringelbach, Bechir Jarraya, Gustavo Deco
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:NeuroImage
Subjects:
Anesthesia
Integration
Ignition
Measures of Consciousness
IIT
GNW
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920311034
id doaj-6038fbb7407641d8b45d09a2ff90c521
record_format Article
spelling doaj-6038fbb7407641d8b45d09a2ff90c5212021-02-11T04:19:08ZengElsevierNeuroImage1095-95722021-02-01227117618Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness lossCamilo Miguel Signorelli0Lynn Uhrig1Morten Kringelbach2Bechir Jarraya3Gustavo Deco4Department of Computer Science, University of Oxford, UK; Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale U992, France; Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Spain; Corresponding authors.Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale U992, France; Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Direction de la Recherche Fondamentale, NeuroSpin Center, France; Department of Anesthesiology and Critical Care, Necker Hospital, University Paris Descartes, France; Department of Anesthesiology and Critical Care, Sainte-Anne Hospital, University Paris Descartes, FranceCenter for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg, Denmark; Centre for Eudaimonia and Human Flourishing, University of Oxford, UK; Department of Psychiatry, University of Oxford, UKCognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale U992, France; Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Direction de la Recherche Fondamentale, NeuroSpin Center, France; Neurosurgery Department, Foch Hospital, Suresnes, France; University of Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, France; Corresponding authors.Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Spain; Department of Information and Communication Technologies, Universitat Pompeu Fabra, Spain; Institució Catalana de la Recerca i Estudis Avançats, Spain; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Germany; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia; Corresponding authors.Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness. Here we suggest that the mechanism of conscious access is related to a general dynamical rearrangement of the intrinsic hierarchical organization of the cortex. To measure cortical hierarchy, we applied the Intrinsic Ignition analysis to resting-state fMRI data acquired in awake and anesthetized macaques. Our results reveal the existence of spatial and temporal hierarchical differences of neural activity within the macaque cortex, with a strong modulation by the depth of anesthesia and the employed anesthetic agent. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics whereas lower values correspond to poor and rigid, structurally driven brain dynamics. Moreover, spatial and temporal hierarchical dimensions are disrupted in a different manner, involving different hierarchical brain networks. All together suggest that disruption of brain hierarchy is a new signature of consciousness loss.http://www.sciencedirect.com/science/article/pii/S1053811920311034AnesthesiaIntegrationIgnitionMeasures of ConsciousnessIITGNW
collection DOAJ
language English
format Article
sources DOAJ
author Camilo Miguel Signorelli
Lynn Uhrig
Morten Kringelbach
Bechir Jarraya
Gustavo Deco
spellingShingle Camilo Miguel Signorelli
Lynn Uhrig
Morten Kringelbach
Bechir Jarraya
Gustavo Deco
Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
NeuroImage
Anesthesia
Integration
Ignition
Measures of Consciousness
IIT
GNW
author_facet Camilo Miguel Signorelli
Lynn Uhrig
Morten Kringelbach
Bechir Jarraya
Gustavo Deco
author_sort Camilo Miguel Signorelli
title Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
title_short Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
title_full Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
title_fullStr Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
title_full_unstemmed Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
title_sort hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss
publisher Elsevier
series NeuroImage
issn 1095-9572
publishDate 2021-02-01
description Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness. Here we suggest that the mechanism of conscious access is related to a general dynamical rearrangement of the intrinsic hierarchical organization of the cortex. To measure cortical hierarchy, we applied the Intrinsic Ignition analysis to resting-state fMRI data acquired in awake and anesthetized macaques. Our results reveal the existence of spatial and temporal hierarchical differences of neural activity within the macaque cortex, with a strong modulation by the depth of anesthesia and the employed anesthetic agent. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics whereas lower values correspond to poor and rigid, structurally driven brain dynamics. Moreover, spatial and temporal hierarchical dimensions are disrupted in a different manner, involving different hierarchical brain networks. All together suggest that disruption of brain hierarchy is a new signature of consciousness loss.
topic Anesthesia
Integration
Ignition
Measures of Consciousness
IIT
GNW
url http://www.sciencedirect.com/science/article/pii/S1053811920311034
work_keys_str_mv AT camilomiguelsignorelli hierarchicaldisruptioninthecortexofanesthetizedmonkeysasanewsignatureofconsciousnessloss
AT lynnuhrig hierarchicaldisruptioninthecortexofanesthetizedmonkeysasanewsignatureofconsciousnessloss
AT mortenkringelbach hierarchicaldisruptioninthecortexofanesthetizedmonkeysasanewsignatureofconsciousnessloss
AT bechirjarraya hierarchicaldisruptioninthecortexofanesthetizedmonkeysasanewsignatureofconsciousnessloss
AT gustavodeco hierarchicaldisruptioninthecortexofanesthetizedmonkeysasanewsignatureofconsciousnessloss
_version_ 1724274665501753344

Similar Items