Evaluation of biochemical marker for bone turnover in post menopausal women

• Main Authors: Keshab Raj Joshi, S P Devi, P P Lanjikar
• Format: Article
• Language: English
• Published: Lumbini Medical College 2013-12-01
• Series: Journal of Lumbini Medical College
• Online Access: https://jlmc.edu.np/index.php/JLMC/article/view/20

Introduction: Menopause is the permanent cessation of menses resulting from reduced ovarian hormone secretion that occurs naturally or is induced by surgery, chemotherapy, or radiation. Aims and objectives: To evaluate the risk of accelerated bone loss by assessing bone markers like alkaline phosphatase (ALP) and calcium in postmenopausal women. Material and methods: The present study was carried out on 100 total subjects out of which experimental group consists of 50 subjects i.e Post menopausal women. Control group consists of 50 subjects Pre menopausal women. Results: The result of the present study suggest that the serum calcium level were signifi cantly reduced but the serum alkaline phosphatase (ALP) levels had a slightly raise in post menopause group when compared to the pre menopause groups. Conclusion: In normal post menopausal women, an increase in bone turnover accelerates the reduction in bone mass, whereas decrease in bone turnover is associated with preservation of bone mass.