Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D

Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D

In our previous study, we found that Ypt1p, a Rab family small GTPase protein, exhibits a stress-driven structural and functional switch from a GTPase to a molecular chaperone, and mediates thermo tolerance in Saccharomyces cerevisiae. In the current study, we focused on the temperature-sensitive yp...

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Bibliographic Details
Main Authors: Chang Ho Kang, Joung Hun Park, Eun Seon Lee, Seol Ki Paeng, Ho Byoung Chae, Yong Hun Chi, Sang Yeol Lee
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
small GTPase
heat-shock
molecular chaperone
structural change
functional switch
Online Access:http://www.mdpi.com/1422-0067/20/1/132

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