A mechanistic account of serotonin’s impact on mood
The cognitive computational mechanisms underlying the antidepressant treatment response of SSRIs is not well understood. Here the authors show that SSRI treatment in healthy subjects for a week manifests as an amplification of the perception of positive outcomes when learning occurs in a positive mo...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16090-2 |
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doaj-6028d947e39345ea83781d5e54358259 |
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Article |
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doaj-6028d947e39345ea83781d5e543582592021-05-11T14:50:26ZengNature Publishing GroupNature Communications2041-17232020-05-0111111110.1038/s41467-020-16090-2A mechanistic account of serotonin’s impact on moodJochen Michely0Eran Eldar1Ingrid M. Martin2Raymond J. Dolan3Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College LondonMax Planck UCL Centre for Computational Psychiatry and Ageing Research, University College LondonWellcome Centre for Human Neuroimaging, University College LondonMax Planck UCL Centre for Computational Psychiatry and Ageing Research, University College LondonThe cognitive computational mechanisms underlying the antidepressant treatment response of SSRIs is not well understood. Here the authors show that SSRI treatment in healthy subjects for a week manifests as an amplification of the perception of positive outcomes when learning occurs in a positive mood setting.https://doi.org/10.1038/s41467-020-16090-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jochen Michely Eran Eldar Ingrid M. Martin Raymond J. Dolan |
| spellingShingle |
Jochen Michely Eran Eldar Ingrid M. Martin Raymond J. Dolan A mechanistic account of serotonin’s impact on mood Nature Communications |
| author_facet |
Jochen Michely Eran Eldar Ingrid M. Martin Raymond J. Dolan |
| author_sort |
Jochen Michely |
| title |
A mechanistic account of serotonin’s impact on mood |
| title_short |
A mechanistic account of serotonin’s impact on mood |
| title_full |
A mechanistic account of serotonin’s impact on mood |
| title_fullStr |
A mechanistic account of serotonin’s impact on mood |
| title_full_unstemmed |
A mechanistic account of serotonin’s impact on mood |
| title_sort |
mechanistic account of serotonin’s impact on mood |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-05-01 |
| description |
The cognitive computational mechanisms underlying the antidepressant treatment response of SSRIs is not well understood. Here the authors show that SSRI treatment in healthy subjects for a week manifests as an amplification of the perception of positive outcomes when learning occurs in a positive mood setting. |
| url |
https://doi.org/10.1038/s41467-020-16090-2 |
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