The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot

The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot

Congenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic stud...

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Main Authors: Amin Safari-Arababadi, Mostafa Behjati-Ardakani, Seyed Mehdi Kalantar, Mojtaba Jaafarinia
Format: Article
Language:English
Published: Zabol University of Medical sciences 2019-06-01
Series:International Journal of Basic Science in Medicine
Subjects:
Congenital heart disease
Tetralogy of Fallot
Gene mutation
Online Access:http://ijbsm.zbmu.ac.ir/PDF/ijbsm-13371
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spelling doaj-6022d9752119434b8bd4765d27db7b582020-11-25T02:42:27ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2019-06-0142455010.15171/ijbsm.2019.10ijbsm-13371The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of FallotAmin Safari-Arababadi0Mostafa Behjati-Ardakani1Seyed Mehdi Kalantar2Mojtaba Jaafarinia3Department of Molecular Genetics, Fars Science and Research Branch, Islamic Azad University, Shiraz, IranYazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranGenetic and Reproductive Unit, Recurrent Abortion Research Centre, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Molecular Genetics, Fars Science and Research Branch, Islamic Azad University, Shiraz, IranCongenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic studies related to CHD are increasing, and each day the role of new genetic markers is more and more clarified, this review re-examined the effects of gene mutations in the pathogenesis of tetralogy of Fallot (TOF) as an important pathological model among other CHDs. Due to the complexity of heart development, it is not astonishing that numerous signaling pathways and transcription factors, and many genes are involved in pathogenesis of TOF. This review focuses on the jag1, nkx2.5, gata4, zfpm2/fog2 and cited2 genes previously reported to be involved in TOF.http://ijbsm.zbmu.ac.ir/PDF/ijbsm-13371Congenital heart diseaseTetralogy of FallotGene mutation
collection DOAJ
language English
format Article
sources DOAJ
author Amin Safari-Arababadi
Mostafa Behjati-Ardakani
Seyed Mehdi Kalantar
Mojtaba Jaafarinia
spellingShingle Amin Safari-Arababadi
Mostafa Behjati-Ardakani
Seyed Mehdi Kalantar
Mojtaba Jaafarinia
The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
International Journal of Basic Science in Medicine
Congenital heart disease
Tetralogy of Fallot
Gene mutation
author_facet Amin Safari-Arababadi
Mostafa Behjati-Ardakani
Seyed Mehdi Kalantar
Mojtaba Jaafarinia
author_sort Amin Safari-Arababadi
title The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
title_short The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
title_full The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
title_fullStr The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
title_full_unstemmed The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
title_sort contribution of gene mutations to the pathogenesisof tetralogy of fallot
publisher Zabol University of Medical sciences
series International Journal of Basic Science in Medicine
issn 2476-664X
publishDate 2019-06-01
description Congenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic studies related to CHD are increasing, and each day the role of new genetic markers is more and more clarified, this review re-examined the effects of gene mutations in the pathogenesis of tetralogy of Fallot (TOF) as an important pathological model among other CHDs. Due to the complexity of heart development, it is not astonishing that numerous signaling pathways and transcription factors, and many genes are involved in pathogenesis of TOF. This review focuses on the jag1, nkx2.5, gata4, zfpm2/fog2 and cited2 genes previously reported to be involved in TOF.
topic Congenital heart disease
Tetralogy of Fallot
Gene mutation
url http://ijbsm.zbmu.ac.ir/PDF/ijbsm-13371
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