Efficacy of inosine pranobex in frequently ill children with chronic Epstein–Barr virus infection: randomized study

• Main Authors: E.N. Simovanyan, V.B. Denisenko, A.V. Grigoryan
• Format: Article
• Language: English
• Published: "Paediatrician" Publishers LLC 2011-01-01
• Series: Voprosy Sovremennoj Pediatrii
• Online Access: http://vsp.spr-journal.ru:80/jour/article/view/562

<p><em>High incidence of acute respiratory infections (ARI) in immunocompromised frequently ill children with chronic Epstein–Barr infection forces the prescription of drugs with complex antivirus and immunocorrecting effect. The objective: to study the efficacy of inosine pranobex (Isoprinosine) in treatment of active Epstein–Barr virus infection in frequently ill children. Methods: patients were randomized in group of standard treatment (n = 24) and standard treatment + inosine pranobex 50 mg/kg of body weight divided to 3–4 parts daily (3 courses of 10 days every other 10 days). Primary efficacy criterion was the incidence of ARI episodes during 12 months of observation. Results: the treatment with inosine pranobex resulted in decrease of incidence (4 and 25%) and duration of ARI (5.6 ± 1.2 and 8.8 ± 3.3 days) compared to standard treatment. Besides, inosine pranobex decreased the frequency of lymphoproliferation, arthralgic and cardiac syndromes, favored to rapid elimination of serologic markers of Epstein–Barr virus replication and normalization of blood concentrations of interferon _ and interleukine 4. Side effects of treatment with inosine pranobex were not registered. Conclusion: inosine pranobex is efficient and safe drug in treatment of active form of chronic Epstein–Barr virus infection in frequently ill children.</em></p><p><em></em><br /><strong><em>Key words: frequently ill children, Epstein–Barr virus, inosine pranobex, treatment.</em></strong></p>