Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell...

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Main Authors: Hui Guo, Faping Li, Heping Qiu, Qi Zheng, Chao Yang, Chao Tang, Yuchuan Hou
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2019/1914976
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spelling doaj-601c513109844142ac29e82c079e16ed2020-11-24T21:03:47ZengHindawi LimitedInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/19149761914976Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer CellsHui Guo0Faping Li1Heping Qiu2Qi Zheng3Chao Yang4Chao Tang5Yuchuan Hou6Department of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaChitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.http://dx.doi.org/10.1155/2019/1914976
collection DOAJ
language English
format Article
sources DOAJ
author Hui Guo
Faping Li
Heping Qiu
Qi Zheng
Chao Yang
Chao Tang
Yuchuan Hou
spellingShingle Hui Guo
Faping Li
Heping Qiu
Qi Zheng
Chao Yang
Chao Tang
Yuchuan Hou
Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
International Journal of Polymer Science
author_facet Hui Guo
Faping Li
Heping Qiu
Qi Zheng
Chao Yang
Chao Tang
Yuchuan Hou
author_sort Hui Guo
title Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
title_short Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
title_full Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
title_fullStr Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
title_full_unstemmed Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
title_sort chitosan-based nanogel enhances chemotherapeutic efficacy of 10-hydroxycamptothecin against human breast cancer cells
publisher Hindawi Limited
series International Journal of Polymer Science
issn 1687-9422
1687-9430
publishDate 2019-01-01
description Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.
url http://dx.doi.org/10.1155/2019/1914976
work_keys_str_mv AT huiguo chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT fapingli chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT hepingqiu chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT qizheng chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT chaoyang chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT chaotang chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
AT yuchuanhou chitosanbasednanogelenhanceschemotherapeuticefficacyof10hydroxycamptothecinagainsthumanbreastcancercells
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