Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone

Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone

Background and Aim. Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods. We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administr...

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Main Authors: Takatsugu Yamamoto, Shun Osumi, Daisuke Yanagisawa, Hiroshi Yamato, Hitoshi Aoyagi, Akari Isono, Koichiro Abe, Hiroto Kita
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/3762179
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spelling doaj-60183d81b7ef4abda6f008d725d9902f2020-11-25T01:08:25ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/37621793762179Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking LubiprostoneTakatsugu Yamamoto0Shun Osumi1Daisuke Yanagisawa2Hiroshi Yamato3Hitoshi Aoyagi4Akari Isono5Koichiro Abe6Hiroto Kita7Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, JapanBackground and Aim. Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods. We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. Results. The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p=0.007). Conclusions. Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.http://dx.doi.org/10.1155/2017/3762179
collection DOAJ
language English
format Article
sources DOAJ
author Takatsugu Yamamoto
Shun Osumi
Daisuke Yanagisawa
Hiroshi Yamato
Hitoshi Aoyagi
Akari Isono
Koichiro Abe
Hiroto Kita
spellingShingle Takatsugu Yamamoto
Shun Osumi
Daisuke Yanagisawa
Hiroshi Yamato
Hitoshi Aoyagi
Akari Isono
Koichiro Abe
Hiroto Kita
Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
BioMed Research International
author_facet Takatsugu Yamamoto
Shun Osumi
Daisuke Yanagisawa
Hiroshi Yamato
Hitoshi Aoyagi
Akari Isono
Koichiro Abe
Hiroto Kita
author_sort Takatsugu Yamamoto
title Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_short Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_full Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_fullStr Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_full_unstemmed Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_sort possible effect of concomitant prokinetics and herbal medicines against nausea in patients taking lubiprostone
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Background and Aim. Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods. We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. Results. The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p=0.007). Conclusions. Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.
url http://dx.doi.org/10.1155/2017/3762179
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