Clinical Value of Concentrations of Inflammation Immunochemical Markers in Blood Serum in Children with Viral Meningitis

• Main Authors: O. G. Kimirilova, G. A. Kharchenko
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2021-01-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; viral meningitis; lactoferrin; ferritin; transferrin; fibrinogen
• Online Access: https://www.ped-perinatology.ru/jour/article/view/1290

A number of the immunochemical markers of inflammation in the blood serum, such as the lactoferrin, transferrin, ferritin, and fibrinogen were identified in 450 patients with the viral meningitis of various etiologies (enterovirus, arbovirus, mumps, adenovirus, and herpesvirus) at 14 years of age. The imbalance of the inflammation markers identified was determined, the severity of which depended on the severity, course and outcome of the disease. The decrease of the lactoferrin concentration by 29% (from 719 to 516 ng/ml) and increase of the ferritin level by 30% (from 70 to 91 ng/ml) by the period of the early convalescence met the heavy severity level of the meningitis. The decrease of the lactoferrin concentration by 2% (from 785 to 770 ng/ml) and increase of the ferritin level by 45% (from 68 to 99 ng/ l) by the period of early convalescence indicated the lingering course of the disease. The concentrations of the transferrin less than 2 g/l (1.74 to 1.68 g/l) and ferritin less than 50 ng/ml (40 to 48 ng/ml) were unfavorable prognosis of for the meningitis outcome.