The Effect of Spatial Smoothing on Representational Similarity in a Simple Motor Paradigm

• Main Authors: Michelle H. A. Hendriks, Nicky Daniels, Felipe Pegado, Hans P. Op de Beeck
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2017-05-01
• Series: Frontiers in Neurology
• Subjects: functional magnetic resonance imaging; multi-voxel pattern analyses; spatial smoothing; primary motor cortex; auditory cortex
• Online Access: http://journal.frontiersin.org/article/10.3389/fneur.2017.00222/full

Multi-voxel pattern analyses (MVPA) are often performed on unsmoothed data, which is very different from the general practice of large smoothing extents in standard voxel-based analyses. In this report, we studied the effect of smoothing on MVPA results in a motor paradigm. Subjects pressed four buttons with two different fingers of the two hands in response to auditory commands. Overall, independent of the degree of smoothing, correlational MVPA showed distinctive patterns for the different hands in all studied regions of interest (motor cortex, prefrontal cortex, and auditory cortices). With regard to the effect of smoothing, our findings suggest that results from correlational MVPA show a minor sensitivity to smoothing. Moderate amounts of smoothing (in this case, 1−4 times the voxel size) improved MVPA correlations, from a slight improvement to large improvements depending on the region involved. None of the regions showed signs of a detrimental effect of moderate levels of smoothing. Even higher amounts of smoothing sometimes had a positive effect, most clearly in low-level auditory cortex. We conclude that smoothing seems to have a minor positive effect on MVPA results, thus researchers should be mindful about the choices they make regarding the level of smoothing.