P2Y12 Receptors in Tumorigenesis and Metastasis

P2Y12 Receptors in Tumorigenesis and Metastasis

Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and metastasis. These effects may occur via direct interaction of platelets with cancer and stromal cells and by the release of several platelet products. Platelets and tumor cells release several bioactive molecule...

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Bibliographic Details
Main Authors: Patrizia Ballerini, Melania Dovizio, Annalisa Bruno, Stefania Tacconelli, Paola Patrignani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
P2Y12
ADP
platelets
cancer
metastasis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00066/full

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