Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation

Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation

The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.

Bibliographic Details
Main Authors: Jose Antonio Escudero, Celine Loot, Vincent Parissi, Aleksandra Nivina, Christiane Bouchier, Didier Mazel
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10937
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spelling doaj-5ff731a853704585826cbd728cd82bf22021-05-11T11:17:12ZengNature Publishing GroupNature Communications2041-17232016-03-017111210.1038/ncomms10937Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovationJose Antonio Escudero0Celine Loot1Vincent Parissi2Aleksandra Nivina3Christiane Bouchier4Didier Mazel5Département Génomes et Génétique, Institut Pasteur, Unité de Plasticité du Génome BactérienDépartement Génomes et Génétique, Institut Pasteur, Unité de Plasticité du Génome BactérienLaboratoire de Microbiologie Fondamentale et Pathogénicité UMR-CNRS 5234Département Génomes et Génétique, Institut Pasteur, Unité de Plasticité du Génome BactérienInstitut Pasteur, Genomic PlatformDépartement Génomes et Génétique, Institut Pasteur, Unité de Plasticité du Génome BactérienThe integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.https://doi.org/10.1038/ncomms10937
collection DOAJ
language English
format Article
sources DOAJ
author Jose Antonio Escudero
Celine Loot
Vincent Parissi
Aleksandra Nivina
Christiane Bouchier
Didier Mazel
spellingShingle Jose Antonio Escudero
Celine Loot
Vincent Parissi
Aleksandra Nivina
Christiane Bouchier
Didier Mazel
Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
Nature Communications
author_facet Jose Antonio Escudero
Celine Loot
Vincent Parissi
Aleksandra Nivina
Christiane Bouchier
Didier Mazel
author_sort Jose Antonio Escudero
title Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
title_short Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
title_full Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
title_fullStr Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
title_full_unstemmed Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
title_sort unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.
url https://doi.org/10.1038/ncomms10937
work_keys_str_mv AT joseantonioescudero unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
AT celineloot unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
AT vincentparissi unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
AT aleksandranivina unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
AT christianebouchier unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
AT didiermazel unmaskingtheancestralactivityofintegronintegrasesrevealsasmoothevolutionarytransitionduringfunctionalinnovation
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