Establishment and characterization of a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation

Establishment and characterization of a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation

Heterozygous T280M mutation in the GATA4 gene, encoding GATA binding protein 4, was recently identified in patients with congenital heart disease (CHD). Here, a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation was generated by using the CRISPR/Cas9 and piggyBac technologies...

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Bibliographic Details
Main Authors:	Lingqun Ye, You Yu, Yong Wang, Ying Huang, Miao Yu, Wei Lei, Jun-Ming Tang, Shijun Hu
Format:	Article
Language:	English
Published:	Elsevier 2021-05-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506121002397

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