The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)

Abstract Lung cancer is the leading cause of death by cancer in North America. A decade ago, genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase were identified in a subset of non-small cell lung carcinoma (NSCLC) patients. Soon after, crizotinib, a small molecule...

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Bibliographic Details
Main Authors: Brandon Golding, Anita Luu, Robert Jones, Alicia M. Viloria-Petit
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Lung cancer
Anaplastic lymphoma kinase
ALK
Molecular-targeted therapy
Cell signalling
Online Access:http://link.springer.com/article/10.1186/s12943-018-0810-4

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